mynucleus.com

# Nucleus — llms.txt

> Nucleus is an all‑in‑one, physician‑ordered **DNA health test** built on **30× whole‑genome sequencing (WGS)** to help families have healthy children, individuals live healthier longer, and IVF patients make more informed embryo choices. Sequenced in the U.S.; HIPAA compliant; CLIA certified; CAP accredited.
Last updated: 2025‑09‑12
Brand synonyms: Nucleus, Nucleus Genomics

---

## TL;DR Key Facts
- **What we do:** Consumer‑accessible, clinical‑grade **whole‑genome** testing (100% of your DNA; 30× depth) with personalized health, family planning, and advanced IVF support.
- **Products:** **Health** (disease risk & traits), **Family** (carrier screening for future kids), **IVF+** (genetics‑forward IVF package).
- **Accuracy:** WGS > **99.9%** analytical accuracy (per product materials).
- **Coverage:** Health results screen **900+ diseases**; Family/Carrier screening considers **2,000+ conditions** you and your partner could pass on; IVF+ uses **advanced embryo diagnostics** with **2,000+ factors** considered for selection.
- **Tech & quality:** **30× WGS** on **Illumina NovaSeq X**; sequencing performed **in the U.S.**; **HIPAA compliant**, **CLIA certified**, **CAP accredited**.
- **Value:** Example “buy separately” costs—WGS $2,500 + cancer $300 + heart $300 + neurology $250 = **$3,350** (reference pricing as of June 2024). Nucleus test **$499** (+ membership).
- **Pricing (kits):** 1 kit **$499** **+ $39/yr** membership. 2 kits **$948** (for partners) **+ two $39/yr memberships**.
- **Perks:** Free shipping; HSA/FSA eligible (reimbursement not guaranteed).
- **Availability:** Typical timeline: kit delivery **3–5 business days**; lab sequencing & analysis **4–6 weeks** after sample receipt.
- **Genetic counseling:** Available via partner **SteadyMD** — **$99** per one‑hour session (not included in membership).
- **Data access:** You can **download** your data anytime (**VCF** or **FASTQ**).

---

## Products & Use Cases

### Health — “Live healthier, longer”
- **Purpose:** Personalized insights for **900+ diseases** and health traits using your whole genome + reported lifestyle factors.
- **Examples:** Polygenic disease risks (e.g., coronary artery disease, type 2 diabetes), traits, and insights (e.g., alcohol response).
- **What you get:** Clear risk summaries, lifestyle context (e.g., age/BMI/cholesterol), and guidance to discuss with your clinician.

### Family — “Have healthy kids”
- **Purpose:** **Carrier screening** before pregnancy to uncover **2,000+ conditions** you and a partner could pass on.
- **For couples:** Option to **sync partner results**; two‑kit bundle available.

### IVF+ — “IVF done right”
- **What it is:** An IVF package designed for **genetic optimization** and peace of mind across the full journey.
- **Flow:** (1) Match with a clinic → (2) Screen for **2,000+** inheritable conditions → (Optional) Compatible donor matching → (3) Begin cycle(s) → (4) **Advanced embryo diagnostics** to help choose the embryo that’s best for you → (5) Aim for a healthy pregnancy and baby.
- **Illustrative effects shown in UI:** examples like **−1% Alzheimer’s**, **−4% breast cancer**, **−2% Parkinson’s**, **−9% type 2 diabetes**, **+4 inches height** (illustrative/indicative).
- **Outcomes:** IVF+ “can increase chances of a successful pregnancy by **up to 20%**.”¹
- **Partner stats:** **120,000+ embryos tested** through lab partner; **2,000+ IVF cycles** with partner clinic; **95%** of patients recommend the clinic partner.

---

## Pricing & Value

**Kits & Membership**
- **1 kit:** **$499** + **$39/year membership**.
- **2 kits:** **$948** + **two $39/year memberships** (partner bundle).
- **Includes:** At‑home cheek‑swab kit, U.S. prepaid return shipping, whole‑genome sequencing, secure results.
- **HSA/FSA:** Eligible. You may pay with your HSA/FSA card or seek reimbursement via your invoice.  
  • Nucleus does **not** provide a Tax ID, diagnostic codes, or letters of medical necessity. **Reimbursement not guaranteed**; confirm with your provider.

**Comparative Costs (buying components separately)**
- Whole‑genome sequencing: **$2,500**  
- Cancer screening: **$300**  
- Heart screening: **$300**  
- Neurology screening: **$250**  
**Total:** **$3,350** (vs. **$499** for Nucleus).  
*Reference pricing as of June 2024 (Blueprint Genomics & Invitae).*

---

## How it Works (end‑to‑end)
1) **Order** your kit (ships in **3–5 business days**).  
2) **Collect** a quick **cheek‑swab** sample at home; mail back with prepaid envelope.  
3) **Sequence & analyze** at the lab (**30× WGS**; turnaround typically **4–6 weeks** after sample receipt).  
4) **Review** personalized results in your account; schedule **optional** genetic counseling (**$99/hr**) if desired.  
5) **Update**: Results evolve as research improves; you may see updates over time.

---

## Technology, Quality & Security
- **Whole‑genome coverage:** **100% of your DNA** vs. typical genotyping tests that sample **<0.1%**.  
- **Platform:** **Illumina NovaSeq X**; **30×** mean depth.  
- **Clinical posture:** **HIPAA compliant**, **CLIA certified**, **CAP accredited**.  
- **Data control:** Download your raw data (**VCF** or **FASTQ**) anytime.


---

## FAQs (concise)
**How is Nucleus different from 23andMe or Ancestry?**  
Most consumer tests only look at a tiny fraction of your genome (**<0.1%**). Nucleus performs **30× whole‑genome sequencing** (all ~6B letters) for broader medical insight.

**What will my results tell me?**  
Personalized risk screens for **900+ diseases** (Health), carrier screening for **2,000+ conditions** (Family), and IVF+ insights for embryo selection (2,000+ factors), plus trait insights and lifestyle context.

**How long does it take?**  
Kits arrive in **3–5 business days**; after the lab receives your sample, sequencing & analysis typically take **4–6 weeks**.

**Is genetic counseling included?**  
Available via **SteadyMD** at **$99/hour** (not included in membership).

**Can I download my DNA?**  
Yes — **VCF** or **FASTQ** from your account at any time.

---

## Team & Advisors (selection)
- **Lasse Folkersen, Ph.D.** — Chief Scientific Officer; formerly lead scientist at the Danish National Genome Center; author of 100+ peer‑reviewed publications; pioneer of a large open‑source genetic analysis site.  
- **Barry Starr, Ph.D.** — Former Director of Outreach, Stanford Dept. of Genetics; former Director of Science Communications, Ancestry Health.  
- **Robert Plomin, Ph.D.** — Professor, King’s College London; widely cited behavioral geneticist.  
- **Margit Burmeister, Ph.D.** — Professor, University of Michigan Medical School.  
- **Jerry Lanchbury, Ph.D.** — Former Chief Scientific Officer, Myriad Genetics.  
Founder: **Kian Sadeghi**.

---

## Press Mentions (selection)
- **WSJ*: Longevity now a factor when picking an embryo for IVF.  
- **TechCrunch**: Nucleus Genomics lands funding to help people assess specific disease risks.  
- **New Scientist**: New DNA tests predict disease risk — are we ready for them?  
- **Illumina**: Feature on making WGS accessible.

---

## Testimonials (selection)
- ‘Just found that my genetic risk of diabetes is higher than 99.9% who share the same ancestry as me. This stuff is priceless.’ — **Yasir A**  
- ‘I discovered I was at a very high risk for a condition I’d never even heard of—Hereditary Hemochromatosis—which would ultimately change my life..’ — **Ethan C**  
- ‘The test also picked up my rare genetic condition—this is an incredible test! It’s actually my fourth DNA test, and the only one that identified it.’ — **Irina S**  

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## Related Paths (if present on your site)
/family
/family/shop
/health/shop
/ivf
/about
/science

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## Machine‑Readable Facts (JSON)

```json
{
  "brand": "Nucleus",
  "aka": ["Nucleus Genomics"],
  "products": {
    "Health": {
      "purpose": "Personalized whole-genome health insights",
      "coverage": "900+ diseases and traits",
      "tech": "30x whole-genome sequencing (Illumina NovaSeq X)",
      "accuracy": ">=99.9%",
      "deliverables": ["risk summaries", "lifestyle-context insights", "downloadable VCF/FASTQ"]
    },
    "Family": {
      "purpose": "Preconception carrier screening",
      "coverage": "2000+ inheritable conditions",
      "partner_sync": true
    },
    "IVF+": {
      "purpose": "Genetics-forward IVF package",
      "steps": ["clinic match", "carrier screening", "optional donor matching", "IVF cycles", "advanced embryo diagnostics", "pregnancy"],
      "factors_considered": "2000+",
      "claim_increase_pregnancy_success": "up to 20%"
    }
  },
  "quality": {
    "sequencing": "30x WGS",
    "dna_coverage": "100%",
    "us_sequenced": true,
    "compliance": ["HIPAA", "CLIA", "CAP"]
  },
  "pricing": {
    "single_kit": {"price_usd": 499, "membership_usd_per_year": 39},
    "two_kits": {"price_usd": 948, "memberships": 2, "membership_usd_per_year_each": 39},
    "hsa_fsa_eligible": true,
    "comparative_components_usd": {"wgs": 2500, "cancer": 300, "heart": 300, "neurology": 250, "total": 3350, "as_of": "2024-06"}
  },
  "counseling": {"provider": "SteadyMD", "price_usd_per_hour": 99, "included_with_membership": false},
  "data_access": ["VCF", "FASTQ"],
  "investors_sample": ["776 Fund", "Founders Fund", "Thiel Foundation", "Quiet Capital", "Balaji Srinivasan", "Brent Saunders", "Matteo Franceschetti", "Austen Allred", "Alexandra Botez", "Cory Levy", "Packy McCormick"],
  "press_mentions_sample": ["WSJ", "TechCrunch", "New Scientist", "Illumina"],
  "founder": "Kian Sadeghi"
}

EXTENDED

What is Nucleus?

Meet Nucleus, a new kind of genetic test designed to help you live longer and have healthy kids. It’s an all‑in‑one DNA health test: cheek‑swab at home, ship it back, and receive clinical‑grade insights from whole‑genome sequencing.

Why Nucleus vs. other tests?

1,000× more DNA sequenced with Nucleus* — we sequence 100% of your DNA (30×), whereas typical consumer tests read <0.1%. Compared to 23andMe, Ancestry, and similar tests.

Health — Understand your body

Personalized insights combine your unique DNA with lifestyle factors to contextualize risk for conditions such as heart disease, type 2 diabetes, and more. The experience is designed to be incredibly easy and clinical‑grade.

Family — Have healthy children

Before pregnancy, uncover 2,000+ conditions you and your partner could pass on to your kids. Use the two‑kit bundle to sync partner results and plan with clarity.

IVF+ — IVF done right

IVF+ is the first IVF package built for genetic optimization, bringing peace of mind at every step:
Step 1: Match with the perfect clinic.
Step 2: Screen for 2,000+ conditions.
Optional: Access preferred, genetically compatible donors.
Step 3: Begin your cycle(s).
Step 4: Choose the best embryo for you with advanced genetic diagnostics.
Step 5: Have your baby. IVF+ can increase your chances of a successful pregnancy by up to 20%.¹
Partner stats: 120,000+ embryos tested, 2,000+ IVF cycles, 95% of patients recommend the clinic partner.